Micky van de Ven Double Halts Everton's Run at Brand New Home Ground
Micky van de Ven became the initial backline player to score two goals in a English top-flight match for Tottenham since the Belgian defender in March 2013.
At a glance
Micky Van de Ven nods into the net twice in first half
Everton's defender has equalizer ruled after VAR review
Senegalese midfielder scores final goal in dying moments
This loss is the Merseyside club's first at Hill Dickinson Stadium
The Tottenham defender scored on two occasions as Spurs extended their winning streak in away games in the Premier League and handed the Toffees their first defeat at their new home.
The Toffees were undefeated in their five previous fixtures at their recently opened stadium at Bramley-Moore Dock, having left their historic home behind after more than a century at the conclusion of last season.
But Tottenham's leader Van de Ven struck twice from corners in the first half to put their impressive record at jeopardy, and they were unable to mount a comeback before Pape Matar Sarr - set up by ex-Everton forward the Brazilian - headed home a final goal to put the game to bed.
Jake O'Brien thought he had levelled the scores a short while after the defender's first goal, directing a bullet header past Guglielmo Vicario from an Everton corner.
The Portuguese striker, meanwhile, missed a handful of opportunities, while Vicario made a succession of fine saves to guarantee the London club went five matches on the road without defeat in the Premier League.
But the VAR stepped in, instructing the match official to review the goal on the pitchside monitor and the referee decided that the winger and Iliman Ndiaye were in offside positions and had impeded with the Spurs keeper.
The win moves the manager's team into third place in the Premier League, a handful of points off local foes and leaders Arsenal.
Everton stay in 14th position and sit six points clear of the drop zone.
Spurs breakdown: The defender fulfils duties at both ends of the field
Following a drab midweek display in the European competition against the French side, where they managed a only two shots on goal, Frank opted for Randal Kolo Muani up front instead of former Toffees player the Brazilian.
The new arrival was failed to influence the game before being substituted for Richarlison after an hour on the field, but it turns out he wasn't needed in the end.
Defender Van de Ven transformed into an offensive threat to be feared.
Tottenham's opening strike came from a cleverly executed corner routine, with Rodrigo Bentancur heading the ball back across the six-yard box for an unmarked Van de Ven to score.
And Ven de Ven - filling in as captain in the Argentine's unavailability - added his second in added time as he outjumped the England keeper to nod in.
The Dutchman was equally outstanding in defence, partnering well with his defensive colleague as the duo handled superbly with the 34 crosses sent their way by the opposition.
Everton analysis: Toffees missing striker's instinct
The club's new home had been a fortress, but it appears the freshness may have worn off somewhat and supporters headed to the exits after the midfielder's final goal for Spurs.
The break in Everton's winning streak at home will not be a major concern for David Moyes, but their striker situation are.
Beto and Thierno Barry - the Toffees' pair of established strikers - had scored only a single goal combined before Sunday's outing.
And they were failed to add to that poor record on a damp and dreary night on in Liverpool.
Beto's performance was summed up when he opted to bicycle-kick a clear chance from close range, despite having room and time to reposition for a more conventional shot that would have challenged Vicario.
Barry, too, was unable to influence the game after replacing the starter in the second half.
It was not for a lack of chance. The majority of Everton's offensive moves came through Grealish and the forward, who tirelessly whipped dangerous crosses into the Spurs box.
What next for both teams?
The Toffees: The team head to the Stadium of Light in the top flight on early November at 20:00 GMT.
Tottenham: Spurs go to St James' Park on late October for their next round League Cup match against Newcastle.